| 山茱萸药材质量评价研究 |
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| 引用本文： | 郝延军,胡静,桑育黎.山茱萸药材质量评价研究[J].辽宁中医杂志,2012(1):126-128. |
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| 作者姓名： | 郝延军 胡静 桑育黎 |
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| 作者单位： | 辽宁省食品药品检验所;沈阳市食品药品检验所;辽宁大学药学院 |
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| 基金项目： | 国家自然科学基金课题(30973866) |
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| 摘 要： | 目的:比较不同产地山茱萸中马钱苷的含量,考察山茱萸药材3年的稳定性和含果核多少对山茱萸中马钱苷含量的影响。方法:采用高效液相色谱梯度洗脱法对山茱萸中马钱苷进行含量测定。结果:马钱苷进样量在0.077376～4.836μg范围内线性关系良好,平均加样回收率为97.9%,RSD=1.30%。结论:不同产地山茱萸药材中马钱苷含量在0.79%～0.92%范围内,药材中马钱苷含量在3年内稳定性良好。未去核山茱萸的马钱苷含量低于0.60%,其他16批山茱萸药材含马钱苷不少于0.60%。
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| 关 键 词： | 山茱萸 马钱苷 梯度洗脱 六味地黄丸 |
Study on Quality Evaluation of Cornus Officinalis |
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| HAO Yan-jun,HU Jing,SANG Yu-li.Study on Quality Evaluation of Cornus Officinalis[J].Liaoning Journal of Traditional Chinese Medicine,2012(1):126-128. |
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| Authors: | HAO Yan-jun HU Jing SANG Yu-li |
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| Institution: | 1.Liaoning Institute for Food and Drug Control,Shenyang 110023,Liaoning,China; 2.Institue of Shenyang City for Food and Drug Control,Shenyang 110005,Liaoning,China; 3.Pharmaceutical College of Liaoning University,Shenyang 110036,Liaoning,China) |
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| Abstract: | Objective:To compare the contents of loganin in Cornus officinalis from different distribution areas;study the quality stability of Cornus officinalis for three years;research the effect of fruit stones to the content of loganin in Cornus officinalis.Methods:The HPLC method was performed on Diamonsil C18(4.6×250mm,5um)column by gradient elution with a mixture liquid of acetonitrile and 0.05%(v/v)phosphoric acid in water.The detective wavelength was 240 nm.Results:The calibration curve of loganin was linear over the range of 0.077376~4.836μg,The average vecovery was 97.9%with RSD 1.3%.Conclusion:The content of loganin in Cornus officinalis from different distribution areas are among 0.79%~0.92%.The quality stability of Cornus officinalis for three years is good.The contents of loganin in Cornus officinalis with fruit stones are less than 0.60%;the others are more than 0.60%. |
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| Keywords: | Cornus officinalis loganin gradient elution Liuwei Dihuang Pill |
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