| 银翘柴桂颗粒对流感病毒FM1感染小鼠免疫功能的影响 |
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| 引用本文： | 李继庭,左俊岭,林培政,焦英杰,王保华,王林.银翘柴桂颗粒对流感病毒FM1感染小鼠免疫功能的影响[J].辽宁中医杂志,2012(3):550-552. |
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| 作者姓名： | 李继庭 左俊岭 林培政 焦英杰 王保华 王林 |
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| 作者单位： | 广东省第二中医院;广州中医药大学第一附属医院 |
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| 基金项目： | 国家“十二五”科技重大专项“重大新药创制”课题(2011ZX09102-009-06);广东省“211工程”三期学科建设项目 |
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| 摘 要： | 目的:研究银翘柴桂颗粒对流感病毒FM1感染小鼠免疫功能的影响。方法:用甲1型流感病毒FM1鼠肺适应株感染小鼠,建立小鼠流感病毒性肺炎的生物模型,用不同浓度银翘柴桂颗粒溶液治疗后,用ELISA方法检测小鼠血清中IFN-γ及细胞因子IL-2、IL-6含量;中性红比色法测定腹腔巨噬细胞的吞噬能力。结果:银翘柴桂颗粒各剂量组均能明显上调小鼠腹腔巨噬细胞的吞噬能力(P<0.01),而中高剂量组能够提高IFN-γ、IL-2活性,同时抑制IL-6的活性(P<0.05)。结论:银翘柴桂颗粒可通过调节机体的免疫功能发挥抗病毒作用。
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| 关 键 词： | 银翘柴桂颗粒 流感病毒 免疫调节 |
Immunomodulatory Effects of Yinqiao Chaigui Granules in mice Infected by Influenza Virus |
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| LI Ji-ting,ZUO Jun-ling,LI Pei-zheng,JIAO Ying-jie,WANG Bao-hua,WANG Lin.Immunomodulatory Effects of Yinqiao Chaigui Granules in mice Infected by Influenza Virus[J].Liaoning Journal of Traditional Chinese Medicine,2012(3):550-552. |
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| Authors: | LI Ji-ting ZUO Jun-ling LI Pei-zheng JIAO Ying-jie WANG Bao-hua WANG Lin |
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| Institution: | 1.Guangdong Second Provincial Traditional Chinese Medicine Hospital,Guangzhou 510095,Guangdong,China; 2.The First Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China) |
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| Abstract: | Objective:To investigate the effects of YinqiaoChaigui granules on immunological function in NIH mice infected by inflenza virus FM1.Methods:The murine pneumonia model was established induced by influenza virus strain A/FM/1/47(H1N1),treated with different dose of YinqiaoChaigui granules.The bioactivities of interferon-γ(IFN-γ),interleuking-2(IL-2) and inerleuking-6 in the murine serum were measured by ELISA.The phagocytic function of murinal celiac macrophage was detected by Neutral Red Colorimetry.Results:Different dose group of YinqiaoChaigui granules up-regulated the phagocyte ability of murinal celiac macrophage.Medium and high dose group of YinqiaoChaigui granules up-regulated bioactivity of IFN-γand IL-2,down-regulated the bioactivity of IL-6.Conclusion:YinqiaoChaigui granules has antiviral effects by regulating the immunological function. |
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| Keywords: | YinqiaoChaigui granules influenza virus immunomodulatory function |
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