知柏地黄汤加味对痤疮患者血清睾酮水平的影响

目的:观察知柏地黄汤对痤疮患者血清睾酮水平的影响及临床疗效。方法:将寻常痤疮患者60例随机分为两组,治疗组30例用知柏地黄汤,对照组30例用维胺酯胶囊,治疗8周后,评价其临床疗效及安全性,并观察60例患者治疗前后外周血的睾酮(T)变化。结果:对照组痊愈6例,痊愈率为20.00%,显效7例,有效12例,总有效率为83.75%。治疗组痊愈7例,痊愈率为23.33%,显效9例,有效10例,总有效率为86.67%。两组比较无统计学差异(P>0.5)。其中对照组痤疮患者体内睾酮(T)水平治疗前后有显著变化(P<0.05),且组间比较差异有统计学意义(P<0.05)。结论:知柏地黄汤对寻常痤疮有确实的疗效,其可能机理在于其能调节患者体内睾酮(T)水平。

Effect of Zhibai Dihuang Decoction on Levels of Testosterone of Acne Patients

Objective:To evaluate the efficacy and security of Zhibai Dihuang Decoction on the treatment of ache,and study its effect on the levels of Testosterone.Methods:60 cases of acne patients were randomly divided into therapeutic group and control group,patients of therapeutic group were treated with Zhibai Dihuang Decoction,and control group were treated with Viaminati.After 8 weeks,therapeutic results and changes of serum levels of Testosterone before and after treatment were measured.Results:In therapeutic group,six patients(20.00%) were cured,7 cases showed markedly effective,and total effective rate was 83.75%;in control group,seven patients(23.33%) were cured,9 cases showed markedly effective,and total effective rate was 86.67%,There Was no significant difference(P>0.5).The levels of Testosterone in therapeutic group were greatly different before and after treatment(P<0.05),and it was greatly different from that of control group(P<0.05).Conclusion:Zhibai Dihuang Decoction has preferable clinic effects.It may take the role through regulating the level of Testosterone.