2型糖尿病患者PAI-1基因、ATN基因多态性与冠心病的关系(附281例分析)

目的：从分子遗传水平对2型糖尿病（2－DM）和冠心病患者进行多基因联合研究，以探讨其内在的相互联系。方法：281例病例均进行血管紧张素转换酶（ACE）基因，血管紧张素肽原（ATN）基因，血浆纤溶酶原激活物抑制因子（PAI－1）基因多态性测定，并进行Logistic多元回归分析。结果：在2－DM组，冠心病者PAI－1基因型频率及等位基因频率明显变化（P＜0．05，P＜0．01），ATN基因型频率及等位基因频率明显变化（P＜0．05，P＜0．01），在非糖尿病组，ATN基因型频率有明显的统计学差异（P＜0．05），Logistic多元回归分析发现，冠心病和年龄，肥胖，PAI－1基因，ATN基因有显著关系。结论：ATN基因多态性可能是冠心病的危险因素，PAI－1基因突变可能主要是2－DM合并冠心病的危险因素。

Relationship between Polymorphisms of PAl-1 Gene,ATN Gene and Coronary HeartDisease in Type 2-DM : Report of 281 Cases

Objective:To explore the relationship between type 2 DM and coronary heart disease (CHD) with mutiple genes analysis.Methods:The polymorphisms of the angiotensin-converting enzyme(ACE) gene, angiotens inogen (ATN)gene,plasminogen activator inhibitor-1 (PAI-1)gene in 281 cases we re analyzed. Results:In DM groups, the frequencies of PAI-1 genotype and 4G allele in CHD patients were increased(P<0.05,P<0.001,respectively ).And in non-DM group, the frequencies of ATN genotype and 4G allele in CHD pat ients were also increased(P<0.05,P<0.001, respectively). In non-DM grou p, the frequencies of ATN genotype in CHD patients were different from non-CHD subjects(P<0.05). In the mutilple regression analyses, CHD were related to a ge, obesity,and PAI-1 gene and ATN gene.Conclusion:Polymorphism of ATN gene may be the rish factor for CHD and PAI-1 gene mutation may be the essential risk factor of CHD with DM.