艾司西酞普兰与度洛西汀对抑郁症患者主观睡眠质量的影响

目的比较艾司西酞普兰与度洛西汀治疗抑郁症患者的疗效以及对主观睡眠质量的影响。方法将80例抑郁症患者随机分为艾司西酞普兰组42例和度洛西汀组38例,疗程均为8周。采用汉密尔顿抑郁量表（HAMD）减分率评定抗抑郁疗效,HAMD睡眠障碍因子和匹兹堡睡眠指数（PSQI）评定睡眠改善效果,不良反应量表（TESS）评定用药的安全性。结果 2种药物的抗抑郁疗效相仿。度洛西汀组治疗后1、2周未HAMD睡眠障碍因子和PSQI评分低于艾司西酞普兰组,差异均有统计学意义（P〈0.05）;但2组治疗4周后比较差异均无统计学意义（P〉0.05）。结论艾司西酞普兰抗抑郁症总体疗效与度洛西汀相当,但治疗早期度洛西汀对患者主观睡眠的改善优于艾司西酞普兰。

Effects of escitalopram and duloxefiue on subjective sleep quality in patients with depression

Objective To compare the curative effects and subjective sleep quality of escitalopram and duloxetine in the treatment of patients with depression. Methods 80 cases of patients with depression were randomly divided into the escita- lopram group and the duloxetine group. The period of treatment was eight weeks. The antidepressant effect was assessed with the drop rate of Hamilton Depression Scale （HAMD） ,the effect of subjective sleep quality was assessed with HAMD sleep dis- turbance factor and the Pittsburgh Sleep Index（PSQI） ,and the administration of security was assessed with vice Treatment E- mergent Symptom Scale （TESS） . Results Both drugs showed similar efficacy in the treatment of depression. In the end of lst,2nd week, duloxetine group was significantly lower than escitalopram group on the HAMD sleep disturbance factor and PSQI, and the difference was statistically significant （P 〈 0.05 ）. After the end of 4th week, the difference was not statistically significant （ P 〉 0.05 ） . Conclusion The clinical effects of escitalopram in treatment of depression are similar to that of duloxetine, but duloxetine can improve subjective sleep quality better in the treatment of early stage.