画钟测验对轻度阿尔茨海默病的诊断作用

目的 探讨画钟测验（CDT）对诊断轻度阿尔茨海默病（AD）患者的敏感度和特异度.方法 轻度AD患者40例,正常对照40例,对所有受试者进行CDT检测,评分采用5分法.应用操作者特征性曲线（ROC）确定CDT对诊断轻度AD的最佳分界值以及诊断的敏感度和特异度.结果 患者组和正常对照组的年龄、性别和教育程度匹配.应用5分评定法,CDT鉴别正常老人和轻度AD的最佳分界值为4分,此时敏感度和特异度分别为90.0%和82.5%.结论 CDT是识别轻度AD患者的一种有效筛查手段.

The validity of the clock drawing test for diagnosing patients with mild Alzheimer's disease

Objective To determine the sensitivity of the clock drawing test （CDT） in differentiaring patients with mild Alzheimer＇s disease from normal elders. Methods CDT was tested in 40 mild AD patients and 40 normal control subjects. The 5 points score method was adopted. The optimal cutoff point, sensitivity, and specificity of the CDT in discriminating between mild AD patients and normal control subjects were established using the receiver operating characteristic curve （ROC）. Results The two groups matched in age, gender, and education. In differentiating mild AD patients and normal control elders, the optimal cutoff point of CDT was 4. A sensitivity of 90.0% and a specificity of 82.5% were obtained, Conclusions CDT was a reliable screening methos for mild AD patients.