Increased frequency of the apolipoprotein E-4 isoform in male subjects with multifactorial hypercholesterolemia |
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| Authors: | Trond P.,Leren ,Anne-Lise, Bbø resen ,Kå re,Berg ,Ingvar,Hjermann Paul,Luren |
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| Affiliation: | University of Oslo, Institute of Medical Genetics;Mcdical School, Medical Out-Patient Clinic, Ullevål Hospital, Oslo, Norway |
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| Abstract: | The apoE polymorphism was studied by two-dimensional gel electrophoresis in serum samples from 62 male subjects with multifactorial hypercholesterolemia and from 63 normal subjects. The apoE-4 isoform was significantly more frequent (p less than 0.02) among the hypercholesterolemic subjects than among the normocholesterolemic controls. |
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| Keywords: | Apolipoprotein E apolipoprotein E polymorphism genetics hypercholesterolemia two-dimensional high resolution gel electrophoresis |
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