Risk factors for capillary leakage syndrome after bone marrow transplantation |
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| Authors: | W. Nürnberger R. Willers S. Burdach U. Göbel |
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| Affiliation: | (1) Department for Paediatric Haematology and Oncology, Heinrich Heine University Medical Center, Düsseldorf, Germany, DE;(2) University Computer Center, Heinrich Heine University, Düsseldorf, Germany, DE |
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| Abstract: | Age, hematopoietic growth factors, cyclosporin A, mode of bone marrow transplantation (BMT) (autologous, allogeneic-related, unrelated), and underlying disease were assessed as potential risk factors for capillary leakage syndrome (CLS) in 96 patients after BMT. CLS was defined as unexplained weight gain of >3% within 24 h and nonresponsiveness to furosemide. CLS occurred in 9/21 patients after unrelated compared with 2/33 after allogeneic-related BMT (p=0.0017) for hematopoietic disorders (n=54) and in 6/7 patients after allogeneic-related compared with 3/35 after autologous BMT (p=0.0001) for solid tumors (n=42). Hematopoietic growth factors and cyclosporin A were no signficant risk factors on their own. We conclude that unrelated BMTs or high-intensity conditioning regimens used in combination with allogeneic-related BMT are the main risk factors for CLS. Received: 6 January 1997 / Accepted: 10 March 1997 |
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| Keywords: | Capillary leakage syndrome Cytokines Endothelial damage Unrelated BMT Pediatric solid tumors |
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