Diclofenac does not modify morphine bioavailability in cancer patients. |
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| Authors: | F De Conno C Ripamonti M Bianchi V Ventafridda A E Panerai |
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| Affiliation: | Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy. |
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| Abstract: | We determined morphine plasma concentrations in 6 cancer patients before and with administration of diclofenac for 5 days. The non-steroidal anti-inflammatory drug does not modify morphine bioavailability. This observation suggests that diclofenac can be used in association with morphine during cancer pain treatment, without increasing the risk of overdosage or side effects of the opiate. |
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