慢性特发性血小板减少性紫癜患者血清转化生长因子-β1测定的意义

目的探讨血清转化生长因子-β1（TGF-β1）在慢性特发性血小板减少性紫癜（ITP）中的临床意义。方法采用双抗体夹心酶联免疫吸附法（ELISA）检测38例初治慢性ITP患者治疗前后血清中TGF-β1水平。结果慢性ITP患者治疗前TGF-β1水平明显高于对照组（P〈0．01）。经治疗缓解后血清TGF-β1水平与治疗前比较明显下降（P〈0．01）。未缓解者TGF-β1水平与初诊患者比较差异无统计学意义（P〉0．05）。TGF-β1水平与血小板数呈负相关（r=-0．342，P〈0．05），与巨核细胞数呈正相关（r=0．409，P〈0．01）。结论TGF-β1参与了慢性ITP的发病，检测TGF-β1水平变化有助于对慢性特发性血小板减少性紫癜患者病情的判断，可作为疗效观察的辅助指标。

Clinical significance of serum level of transforming growth factor-beta 1 in patients with chronic idiopathic thrombocytopenic purpura

Objective To investigate clinical significance of transforming growth factor-beta 1 （TGF-β1） in patients with chronic idiopathic thrombocytopenic purpura（ITP）. Methods level in the serum 38 patients with initial chronic ITP were detected using enzyme-linked immunosorbent assay（ELISA）. Results The serum level of TGF-β1 in initial patients with chronic ITP was significantly higher than level of controls（ P 〈 10.01 ） ,The serum level of TGF-β1 in those having good response after therapy was significantly lower than before treatment（ P 〈 10.01 ）. There were no difference in TGF-β1 between nonremission and initial patients （P 〉 0.05 ）. There were negative correlation between TGF-β1 and platelet count （r = -0. 342 ,P 〈 10.05 ） , There were positive correlation between TGF-β1 and megakaryocyte count （ r = 0. 409, P 〈 10.01 ）. Conclusion TGF-β1 partakes of the pathogenesis in chronic ITP,the level of TGF-β1 in the patients with chronic ITP is useful to judge state of illness, and TGF-β1 was regarded as assistant index of curative effect.