Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature |
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Authors: | Taaning Ellen Jensen Lise Varming Kim |
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Affiliation: | Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Denmark. ellen.morling.taaning@rh.regionh.dk |
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Abstract: | Foetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia caused by maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding caused by maternal anti-HPA-3a alloantibodies and mild neutropenia caused by maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions. CONCLUSION: This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays. |
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Keywords: | Allo‐HPA‐3a Auto‐HNA‐1b Neonate Neutropenia Thrombocytopenia |
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