Detection of the plasmid-mediated quinolone resistance determinants in clinical isolates of Acinetobacter baumannii in China |
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| Authors: | Haifei Yang Lifen Hu Yanyan Liu Ying Ye |
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| Affiliation: | 1. Department of Infectious Disease, the First Affiliated Hospital of Anhui Medical University, Hefei, China;2. Institute of Bacterium Resistance, Anhui Medical University, Hefei, China;3. Anhui Center for Surveillance of Bacterial Resistance, Hefei, China;4. Institute of Bacterium Resistance, Anhui Medical University, Hefei, China |
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| Abstract: | We examined the prevalence of plasmid–mediated quinolone resistance (PMQR) determinants among Acinetobacter baumannii in Anhui, China. And β–lactamase genes and mutations in quinolone resistance–determining regions (QRDRs) were also investigated among the PMQR-positive isolates. Among the 39 A. baumannii isolates, 3 (7.7%) isolates harbored qnrB and 1 (2.6%) harbored qnrS. Mutations in the QRDRs of gyrA were identified in 2 isolates amongst the 4 PMQR-positive isolates. Quinolone resistance could be transferred by conjugation from all 4 PMQR-positive donors. In conclusion, more attention should be taken to prevent the transmission of PMQR genes among A. baumannii. |
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| Keywords: | Acinetobacter baumannii PMQR QnrB QnrS QRDRs |
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