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Detection and characterization of OXA-48-producing Klebsiella pneumoniae originated in Bulgaria |
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| Authors: | Stefana Sabtcheva Ivan N. Ivanov Bozhana Todorova Yordan Simeonov Elina Dobreva Krasimira Ivanova |
| Affiliation: | 1. Laboratory for Clinical Microbiology, National Oncology Center – SHATO, Sofia, Bulgaria;2. National Reference Laboratory for Control and Monitoring of Antibiotic Resistance, Department of Microbiology, National Center of Infectious and Parasitic Diseases, Bulgaria;3. Department of Surgery, Specialized Hospital for Active Treatment in Oncology – SHATO, Sofia, Bulgaria |
| Abstract: | We report the identification of OXA-48-producing Klebsiella pneumoniae, causing peritonitis in a cancer patient admitted to the Oncology Hospital in Sofia. The isolate had reduced susceptibility to carbapenems but remained susceptible to extended-spectrum cephalosporins. PCR and sequencing confirmed the presence of blaOXA-48 gene flanked by two intact copies of IS1999 on truncated ΔTn1999.1. This transposon was located on unusual non-typeable 29-kb plasmid that could be transferred only by transformation. Multilocus sequence typing (MLST) indicated the presence of the sequence type ST530.This is the first documented infection due to OXA-48-producing Enterobacteriaceae strain in Bulgaria. |
| Keywords: | Carbapenem resistance Oxacillinases OXA-48 Klebsiella pneumoniae |