益气养阴法对系统性红斑狼疮缓解期撤减激素的影响

目的：观察以益乞养阴法为主治疗系统性红斑狼疮（SLE）缓解期撤减皮质激素的疗效及对部分免疫指标的影响。方法：选择SLE患者40例（治疗组30例、对照组10例），急性进展期均用皮质激素及（或）免疫抑制剂常规治疗，治疗组于缓解期加用益气养阴汤。结果：总有效率治疗组为93．3％，对照组为90．0％，治疗组疗效优于对照组（P＜0．05）；在改善免疫指标（IgG及补体C3）方面，治疗组治疗前后比较差异有显著性（P＜0．01）。强的松维持量治疗组为（7．08±5．26）mg/d，对照组为（11．72±6．48）mg/d，两组比较差异有显著性（P＜0．05）。结论：应用益气养阴法为主治疗缓解期SLE能较为顺利地撤减皮质激素，消除症状，改善机体免疫功能。

Clinical Observation on Effect of Yiqi Yangyin Principle on Corticosteroid Withdrawal in Patients with Systemic Lupus Erythematosus at Remission Stage

OBJECTIVE: To observe the therapeutic effect of Yiqi Yangyin principle (YQYY, the treating principle in TCM to supplement Qi and nourish Yin) on corticosteroid withdrawal in patients with systemic lupus erythematosus (SLE) in remission stage and its influence on some immune parameters. METHODS: The SLE patients were divided into two groups, 30 in the treated group and 10 in the control group, who were treated by conventional method with corticosteroids and/or immunosuppressant in acute progressive stage, and YQYY was added to the treated group in remission stage. RESULTS: The total effective rate was 93.3% in the treated group and 90.0% in the control group, comparison between the two groups showed significant difference by Ridit test (P < 0.05). The immune parameters, IgG and C3 were significantly improved after treatment in the treated group (P < 0.01), but changed insignificantly in the control group. The maintaining dose of prednisone used in the two groups was 7.08 +/- 5.26 mg/d and 11.72 +/- 6.48 mg/d respectively, the amount used in the treated group was significantly lower than that in the control. CONCLUSION: Using mainly YQYY Principle to treat SLE in remission stage could withdraw the corticosteroid smoothly, relieve symptoms and improve immune function.