Bone marrow involvement in diffuse large B-cell lymphoma: correlation between FDG-PET uptake and type of cellular infiltrate |
| |
Authors: | Gaetano Paone Emmanuel Itti Corinne Haioun Philippe Gaulard Jehan Dupuis Chieh Lin Michel Meignan |
| |
Institution: | 1.Department of Nuclear Medicine, H?pital Henri Mondor, Assistance Publique-H?pitaux de Paris (AP-HP),Université Paris 12,Créteil,France;2.Department of Clinical Haematology, H?pital Henri Mondor, Assistance Publique-H?pitaux de Paris (AP-HP),Université Paris 12,Créteil,France;3.Department of Pathology, H?pital Henri Mondor, Assistance Publique-H?pitaux de Paris (AP-HP),Université Paris 12,Créteil,France;4.INSERM U841, H?pital Henri Mondor, Assistance Publique-H?pitaux de Paris (AP-HP),Université Paris 12,Créteil,France |
| |
Abstract: | Purpose To assess, in patients with diffuse large B-cell lymphoma (DLBCL), whether the low sensitivity of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for bone marrow assessment may be explained by histological characteristics
of the cellular infiltrate.
Methods From a prospective cohort of 110 patients with newly diagnosed aggressive lymphoma, 21 patients with DLBCL had bone marrow
involvement. Pretherapeutic FDG-PET images were interpreted visually and semiquantitatively, then correlated with the type
of cellular infiltrate and known prognostic factors.
Results Of these 21 patients, 7 (33%) had lymphoid infiltrates with a prominent component of large transformed lymphoid cells (concordant
bone marrow involvement, CBMI) and 14 (67%) had lymphoid infiltrates composed of small cells (discordant bone marrow involvement,
DBMI). Only 10 patients (48%) had abnormal bone marrow FDG uptake, 6 of the 7 with CBMI and 4 of the 14 with DBMI. Therefore,
FDG-PET positivity in the bone marrow was significantly associated with CBMI, while FDG-PET negativity was associated with
DBMI (Fisher’s exact test, p=0.024). There were no significant differences in gender, age and overall survival between patients with CBMI and DBMI, while
the international prognostic index was significantly higher in patients with CBMI.
Conclusion Our study suggests that in patients with DLBCL with bone marrow involvement bone marrow FDG uptake depends on two types of
infiltrate, comprising small (DBMI) or large (CBMI) cells. This may explain the apparent low sensitivity of FDG-PET previously
reported for detecting bone marrow involvement. |
| |
Keywords: | 18F-FDG-PET Lymphoma Bone marrow involvement |
本文献已被 SpringerLink 等数据库收录! |
|