Indole/isatin-containing hybrids as potential antibacterial agents |
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| Authors: | Feng Song Zhenghua Li Yunqiang Bian Xiankai Huo Junman Fang Linlin Shao Meng Zhou |
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| Affiliation: | 1. Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, Shandong, China;2. Department of Medical Imaging, Dezhou People's Hospital, Dezhou, Shandong, China;3. School of Life Sciences, Dezhou University, Dezhou, Shandong, China |
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| Abstract: | The emergence and worldwide spread of drug-resistant bacteria have already posed a serious threat to human life, creating the urgent need to develop potent and novel antibacterial drug candidates with high efficacy. Indole and isatin (indole-2,3-dione) present a wide structural and mechanistic diversity, so their derivatives possess various pharmacological properties and occupy a salient place in the development of new drugs. Indole/isatin-containing hybrids, which demonstrate a promising activity against a panel of clinically important Gram-positive and Gram-negative bacteria, are privileged scaffolds for the discovery of novel antibacterial candidates. This review, covering articles published between January 2015 and May 2020, focuses on the development and structure–activity relationship (SAR) of indole/isatin-containing hybrids with potential application for fighting bacterial infections, to facilitate further rational design of novel drug candidates. |
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| Keywords: | antibacterial drug resistance hybrid compounds indole isatin structure–activity relationship |
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