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Coumarin derivatives with anticancer activities: An update |
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| Authors: | Xu-Feng Song Jing Fan Lan Liu Xiao-Feng Liu Feng Gao |
| Affiliation: | 1. Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing, China;2. Hengshui University, Hengshui, Hebei, China;3. Medicine Vocational and Technical School, Wuhan University, Wuhan, Hubei, China;4. Sinolite Industrial Co., Ltd., Hangzhou, Zhejiang, China;5. State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong, China |
| Abstract: | Cancer can invade or spread to almost all parts of the body. The increasing morbidity and high mortality of cancer create a great demand for the development of novel anticancer drugs. Coumarin derivatives are ubiquitous in nature and can readily interact with diverse enzymes and receptors in cancer cells via weak bond interactions; hence, coumarin is a highly privileged pharmacophore for the development of novel anticancer agents. This review will focus on the recent development of coumarin hybrids as potential anticancer agents covering articles published from 2019 to 2020. |
| Keywords: | anticancer coumarin drug discovery mechanism of action |