RETRACTED: MiR-93 blocks cell cycle progression and promotes apoptosis in uterine leiomyoma cells by targeting CCND1 |
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| Authors: | Donghong Zhang Enling Liu Wei Tian Zhiyong Zhang Liqun Wang Jun Li |
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| Affiliation: | 1. Obstetrics and Gynecology, , Tangshan Gongren Hospital, Tangshan, Hebei Province, China;2. Experimental Diagnostics, Tangshan Gongren Hospital, Tangshan, Hebei Province, China |
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| Abstract: | Uterine leiomyoma (UL) is the most common type of benign tumor in the women's reproductive system. A number of genes has been found to play an important role in the initiation and progression of UL, including miRNAs. In this study, our results exhibited that miR-93, a member of mir-106b-25 cluster, significantly reduced the cell viability, promoted cell cycle arrest, caused apoptosis, and inhibited migration in UL cells (p < .01). Moreover, our results have provided experimental evidence that miR-93 regulated the biological functions of UL cells by targeting CCND1. |
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| Keywords: | CCND1 miR-93 uterine leiomyoma |
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