643例非淋菌性尿道炎患者支原体感染及药敏结果分析

目的了解非淋菌性尿道炎患者支原体感染及耐药性情况,为临床提供最新的流行病学资料及合理用药的科学依据。方法应用深圳银科支原体检测试剂盒对643例疑似支原体感染患者进行了支原体培养及药敏试验,并对结果进行统计分析。结果支原体总检出率为48.83%,女性检出率(59.71%)明显高于男性(30.08%),差异有统计学意义(P0.01),解脲支原体(Uu)阳性率(36.39%)明显高于人型支原体(Mh)阳性率(1.87%)及Uu合并Mh感染阳性率(10.58%)。支原体对环丙沙星、氧氟沙星、罗红霉素、螺旋霉素和左旋氧氟沙星耐药率均超过70.00%,而强力霉素、美满霉素、克拉霉素和交沙霉素对支原体较为敏感。结论非淋菌性尿道炎患者支原体感染以Uu比较常见,且女性检出率显著高于男性。临床分离支原体大多具有多重耐药性和高耐药性,临床治疗需根据药敏结果加以选择。

Analysis on infection and drug resistance of Mycoplasma in 643 patients with NGU

Objective To investigate the infection and drug resistance of Mycoplasma in the patients with non-gonococcal urethritis（NGU）.Methods Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） as well as their drug susceptibilities were tested by using the mycoplasma detection kits produced by Shenzhen Yinke.Results The total infection rate was 48.83% in 643 patients with NGU.The infection rate in feminine（59.71%） was obviously higher than that in masculine（30.08%）（P〈0.01）.Only Uu positive rate（36.39%） was higher than both Uu and Mh positive rate（10.58%） and only Mh positive rate（1.87%）（P〈0.01）.The resistant rates to ciprofloxacin,kfloxacin,roxithromycin,spiramycin and levofloxacin were all higher than 70.00%.Doxycyclinen,minocycline,clarithromycin and josamycin were sensitive to Mycoplasma.Conclusion The infection of Uu is common in the patients of NGU and the infection rate in feminine is higher than that in masculine.Antimicrobial agents should be chosen according to antimicrobial susceptibility test results because of their high and multi-drug resistance.