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| 脂蛋白脂酶基因PvuⅡ酶切位点多态性与胰岛素抵抗关系的研究 | |
| 引用本文： | 崔晓栋,张晓芸,姜妙娜,宋林萱,葛光岩,贾玉杰. 脂蛋白脂酶基因PvuⅡ酶切位点多态性与胰岛素抵抗关系的研究[J]. 中国实用医药, 2008, 3(3): 20-21 |
| 作者姓名： | 崔晓栋 张晓芸 姜妙娜 宋林萱 葛光岩 贾玉杰 |
| 作者单位： | 1. 山东省潍坊医学院病理生理教研室,261041 2. 潍坊生理教研室,张晓芸 3. 大连医科大学病理生理教研室 4. 大连市第二人民医院内分泌科 5. 大连市第三人民医院 |
| 摘 要： | 目的旨在探讨脂蛋白脂酶基因第6内含子PvuⅡ酶切位点多态性与胰岛素抵抗、2型糖尿病的发生之间是否有关联。方法随机选取163例2型糖尿病患者作为病例组，106例正常人作为正常对照组，对第6号内含子PvuⅡI酶切位点进行多态性分析。结果病例组中P＋P＋组高密度脂蛋白胆固醇水平明显低于P-P-组，而血清三酰甘油、胰岛素抵抗指数指标水平高于P-P-组。结论PvuⅡ酶切位点多态性与2型糖尿病中胰岛素抵抗有关。 |
| 关 键 词： | 2型糖尿病 胰岛素抵抗 脂蛋白脂酶基因 酶切位点多态性 |
DNA polymorphism of pvuII sites in the lipoprotein lipase gene in patients with insulin resistance |
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| CUI Xiao-dong , ZHANG Xiao-yun, JIANG Miao-na,et al.. DNA polymorphism of pvuII sites in the lipoprotein lipase gene in patients with insulin resistance[J]. China Practical Medical, 2008, 3(3): 20-21 | |
| Authors: | CUI Xiao-dong ZHANG Xiao-yun JIANG Miao-na et al. |
| Affiliation: | CUI Xiao-dong , ZHANG Xiao-yun, JIANG Miao-na, et al. |
| Abstract: | Objective To investigate the frequency of variant of lipoprotein lipase(LPL)gene,PvuII at intron 6,and its relation to insulin resistance(IR)in type 2 diabetes mellitus.Methods PCR-RFLP method was used to determine the DNA polymorphism of 6th intron at LPL gene in 163 type 2 diabetes(T2DM)patients and 106 controls.Results The levels of TG and IR in P P genotype were higher than those in P-P-genotype(P<0.05),but HDL-C was lower(P<0.05).Conclusion The LPL-PvuII-RFLP is significantly associated with insulin resistance in type 2 diabetes. |
| Keywords: | Type 2 diabetes mellitus(T2DM) Insulin resistance Lipoprotein lipase(LPL)gene Restriction fragment length polymorphism(RFLP) |
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