持续气道内正压通气对阻塞性睡眠呼吸暂停综合征患者脑血流频谱的影响

目的　观察持续气道内正压通气（ｎＣＰＡＰ）治疗对阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）脑血流频谱及血流变学的影响。方法　通过分析多导睡眠图（ＰＳＧ）了解１５例患者ｎＣＰＡＰ治疗前和治疗３个月、６个月时脑血流频谱及血流变学变化情况，以及脑血流频谱与呼吸紊乱指数（ＡＨＩ）、血氧饱和度（ＳａＯ２％ ）的关系。结果　ｎＣＰＡＰ治疗３个月，ＰＳＧ 显示ＯＳＡＳ患者的ＡＨＩ及ＳａＯ２％ 均有明显改善，但脑血流经颅多普勒（ＴＣＤ）及血流变学的各项指标改善不明显（Ｐ＞ ０．０５） 。治疗６个月的ＯＳＡＳ患者呼吸暂停时间（ＡＩ）较治疗３个月又有所下降，ＳａＯ２％ 上升，同时ＴＣＤ 及血流变学也明显改善。结论　ｎＣＰＡＰ治疗ＯＳＡＳ患者６个月以上可明显改善脑供血不足，明显降低血液粘稠度。

Effect of Continuous Positive Airway Pressure Treatment on Cerebral Blood Flow Velocities of Obstructive Sleep Apnea Syndrome Patients

Objective To observe the effects of continuous positve airway pressure (CPAP) treatment on cerebral blood flow velocities of obstructive sleep apnea syndrome (OSAS) patients. Methods Through polysomnography (PSG) 15 cases with OSAS were known for their cerebral blood flow velocity changes and the relationship among cerebral blood flow velocities and apnea hypopnea index (AHI) and SaO 2%. Results The patients were treated by nCPAP for 3 months their PSG showed an obvious improvement in AHI and SaO 2%. But no significant changes in TCD and hemorrheology. For 6 months all the above indexes further improved. Conclusion SOAS patients were treated by nCPAP for over 6 months the cerebral blood flow speech improved obviously and whole blood hematorit recuced.