前列腺癌内分泌治疗疗效的MRI评价

目的 用ＭＲＩ定量评价前列腺癌内分泌疗法的治疗效果。方法 ２０例经病理证实的前列腺癌患者用分泌疗法平均治疗１１０ｄ，对治疗前后的ＭＲＩ表现进行比较。结果 内分泌疗法治疗约１１０ｄ，前列腺、肿瘤部分和非肿瘤部分体积分别减少了５１．５６％（ｔ＝１９．３４，Ｐ〈０．０５）、８０．８７％（ｔ＝９．７６，Ｐ〈０．０５）和４８．９４％（ｔ＝１７．１７，Ｐ〈０．０５），提示肿瘤部分较非肿瘤部分对分泌治疗更敏感。

Effectsof endocrine therapy on the primary lesions in patients with prostate cancer as evaluatedby magnetic resonance imaging

Objective To investigate the quantitative effects of endocrine therapy on the primary prostate cancer using MRI Methods The primary cancer was evaluated by MRI approximately 110 days after the initiation of endocrine therapy in 20 patients with histologically confirmed prostate carcinoma detected by MRI before therapy Results The volumes of the prostate gland, the carcinoma, and the noncarcinomatous components were reduced 51 56%, 80 87% and 48 94% of their pretreatment volumes respectively after endocrine therapy, indicating that the tumors were more susceptible to endocrine therapy than the nontumourous components On T 2WI the peripheral zone showed homogeneous decreases in signal intensity in 8 of 20 patients, making it difficult to differentiate the tumorous and nontumorous portion The seminal vesicles showed decreased volume bilaterally, and 14 of the 20 patients yielded symmetrical low signal intensities Conclusion MRI is the method of choice in the follow up of the endocrine therapy of the primary prostate cancer This study suggests that downsizing of the prostate cancer may occur after endocrine therapy In addition, the tissue of the prostate cancer might be more sensitive to the endocrine therapy than the residual noncancerous prostate gland However, when the normal high signal intensities of the peripheral zone decrease significantly in the T 2 weighted images, we could hardly differentiate the normal tissue from the prostate cancers after endocrine therapy