Plateletpheresis: comparison of platelet yields, processing time, and white cell content with two apheresis systems

Two apheresis systems (COBE Spectra and Fenwal CS-3000 Plus with TNX-6 chamber CS-3000 Plus]) were compared by using their yield predictors and maximum processing times in regard to platelet yields and processing times (n = 200 each). Platelet yields (n = 50 each) and white cell (WBC) content (n = 20 each) from procedures using the current software revision (3.6) on the Spectra and various interface offset (IO) settings on the CS-3000 Plus were also compared. Significantly higher median platelet yields (4.88 range, 1.84-9.97] vs. 4.57 range, 2.82-9.20] × 10(11) platelets) and frequency of components with > or = 6.0 × 10(11) platelets (31.5 vs. 21.5%) were found with the Spectra. In the study with Spectra and the CS-3000 Plus IO settings, IO-10 and IO-13, overall, produced the most platelets, although the differences were not significant. All Spectra collections tested had < 5 × 10(8) WBCs, and, depending on the software revision, had either 85 percent (revision 3.6) or 100 percent (revision 2.5) of components with < 5 × 10(6) WBCs. To ensure that 100 percent of components contained < 5 × 10(8) WBCs when the CS-3000 Plus was used, IO settings of 10 or less were required, and to ensure components with < 5 × 10(6) WBCs, only IO-6 could be used. Spectra and CS-3000 Plus were capable of collecting large doses of platelets (up to the equivalent of 18 units) in processing times of 67 to 100 minutes with < 5 × 10(6) WBCs.