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| 表观遗传学与女性生殖及辅助生殖技术 | |
| 引用本文： | 高敏芝,赵晓明,张慧琴.表观遗传学与女性生殖及辅助生殖技术[J].生殖医学杂志,2009,18(1):61-66. |
| 作者姓名： | 高敏芝 赵晓明 张慧琴 |
| 作者单位： | 1. 上海交通大学医学院附属仁济医院生殖医学科;上海,200001复旦大学上海医学院,上海,200032 2. 上海交通大学医学院附属仁济医院生殖医学科,上海,200001 3. 复旦大学上海医学院,上海,200032 |
| 摘 要： | 表观遗传过程主要以DNA甲基化形式进行修饰，其中基因印迹在女性生殖和辅助生殖技术中有重要作用。本文就表观遗传修饰的方式、与女性生殖的相关性、表观遗传异常对女性生殖和辅助生殖技术后代的影响等进行阐述，表观遗传的调节尚需深入研究。 |
| 关 键 词： | 表观遗传学 DNA甲基化 基因印迹 辅助生殖技术 |
Epigenetics and female reproduction and assisted reproductive technology |
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| GAO Min-zhi,ZHAO Xiao-ming,ZHANG Hui-qin.Epigenetics and female reproduction and assisted reproductive technology[J].Journal of Reproductive Medicine,2009,18(1):61-66. | |
| Authors: | GAO Min-zhi ZHAO Xiao-ming ZHANG Hui-qin |
| Institution: | GAO Min-zhi , ZHAO Xiao-ming, ZHANG Hui-qin( 1. Department of Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001 2. Shanghai Medical College of Fudan University, Shanghai 200032) |
| Abstract: | Epigenetic process is modified mainly by DNA methylation, during which genomic imprinting plays an important role in female reproduction and assisted reproductive technology （ART）. This review details on the patterns of epigenetic modification, its association with female reproduction and the effect of epigenetie variation on female reproduction and ART offspring. The regulation of epigenetics still needs further understanding. |
| Keywords: | Epigenetics DNA methylation Genomic imprinting Assisted reproductive technology |
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