Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice |
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Authors: | Puoliväli Jukka Wang Jun Heikkinen Taneli Heikkilä Matti Tapiola Tero van Groen Thomas Tanila Heikki |
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Affiliation: | Department of Neuroscience and Neurology, University of Kuopio, Finland. Jukka.Puolivali@uku.fi |
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Abstract: | We investigated the role of hippocampal amyloid pathology in spatial learning impairment of a new mouse line carrying mutated human amyloid precursor protein (APP) and presenilin-1 (PS1) transgenes. The APP + PS1 mice were tested in spatial navigation in the water maze and in position discrimination in the T-maze at ages of 3-4 and 11-12 months, before and after the appearance of first amyloid plaques. The APP + PS1 mice were impaired in water maze acquisition and retention only at the age of 11-12 months, but performed equally to controls in the T-maze task at both ages. In the impaired older age group, the levels of total Abeta1-42 in the hippocampus of APP + PS1 mice correlated negatively with the retention score. Here we show for the first time that the age-dependent impairment in memory retention in the traditional water maze of APP + PS1 mice correlates with the amount of total Abeta in hippocampus even at a stage when the amyloid deposits cover less than 1% of the hippocampal volume. |
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