SUMO-1基因rs7580433多态性与非综合征性唇腭裂的关联研究 |
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引用本文: | 宋涛,焦晓辉,赵辉,叶向梅. SUMO-1基因rs7580433多态性与非综合征性唇腭裂的关联研究[J]. 口腔医学研究, 2009, 25(2): 135-137 |
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作者姓名: | 宋涛 焦晓辉 赵辉 叶向梅 |
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作者单位: | 1. 哈尔滨医科大学口腔医院口腔颌面外科,黑龙江,哈尔滨,150001 2. 哈尔滨医科大学附属第一医院中心实验室 |
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基金项目: | 黑龙江省自然科学基金 |
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摘 要: | 目的:研究SUMO-1基因rs7580433的多态性与中国人群非综合征性唇腭裂(NSCLP)的相关性。方法:从国际人类基因组单体型图计划(HapMap)选取来自中国北京汉族人群的多态位点rs7580433为研究位点,在183名NSCLP患者和162名健康正常人对此位点进行基因分型从而进行病例-对照研究。结果:NSCLP患者的GA基因型频率比正常对照组明显降低,其差异有统计学意义(P=0.025)。结论:SUMO-1基因rs7580433位点的基因多态性与中国人群NSCLP易感性相关。
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关 键 词: | SUMO-1 非综合征唇腭裂 唇裂 腭裂 关联研究 |
Association between rs7580433 Variation in SUMO-1 and Nonsyndromic Cleft Lip with or without Cleft Palate |
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Affiliation: | SONG Tao,JIAO Xiao-hui,ZHAO Hui,et al. (Department of Oral Maxillofacial Surgery,School of Stomatology,Harbin Medical University,Harbin 150001) |
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Abstract: | Objective:To investigate the potential association between rs7580433 markers in SUMO-1 (the small ubiquitin-like modifier-1) and the risk of human NSCLP (Nonsyndromic cleft lip with or without cleft palate). Methods:rs7580433 in SUMO-1 from HapMap data on Chinese Han from Beijing was analysed in 183 patients and 162 healthy controls. Results:There was statistically difference in the GA genotypes between the cases and the control. (P=0.025). Conclusion:SUMO-1 gene variation was associated with the NSCLP developmentof Chinese Han. |
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Keywords: | SUMO-1 |
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