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| Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005： Exploratory screening reveals high frequency of occult HBV infection | |
| 作者姓名： | Bhattacharya P Chandra PK Datta S Banerjee A Chakraborty S Rajendran K Basu SK Bhattacharya SK Chakravarty R |
| 作者单位： | Institute of Blood Transfusion Medicine and Immunohematology Kolkata India,ICMR Virus Unit Kolkata India,ICMR Virus Unit Kolkata India,ICMR Virus Unit Kolkata India,Institute of Blood Transfusion Medicine and Immunohematology Kolkata India,National Institute of Cholera and Enteric Diseases Kolkata India,Institute of Blood Transfusion Medicine and Immunohematology Kolkata India,National Institute of Cholera and Enteric Diseases Kolkata India,ICMR Virus Unit Kolkata India |
| 基金项目： | grants partly from West Bengal State AIDS Prevention & Control Society, Kolkata and partly by Indian Council of Medical Research, New Delhi. Partha Kumar Chandra received a research associateship from West Bengal State AIDS Prevention & Control Society, Kolkata. Arup Banerjee received a senior research fellowship from Indian Council of Medical Research New Delhi,Sibnarayan Datta received a senior research fellowship from University Grants Commission, New Delhi |
| 摘 要： | AIM： To evaluate the prevalence of markers of hepatitis B virus （HBV） and hepatitis C virus （HCV） and human immunodeficiency virus （HIV） among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen （HBsAg） negative but anti-HBc positive blood donors. METHODS： Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113051 and 106695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS： A statistically significant increase in the prevalence of HBV （1448 vs 1768, P 〈 0.001）, HIV （262 vs 374, P 〈 0.001）, HCV （314 vs 372, P = 0.003） and syphilis （772 vs 853, P = 0.001） infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 （18.3%）of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION： The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. |
| 关 键 词： | 乙肝病毒 人体免疫缺陷病毒 丙肝病毒 血液捐赠 病毒感染 |
| 收稿时间： | 2007 Jan 2 |
Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: exploratory screening reveals high frequency of occult HBV infection |
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| Bhattacharya P,Chandra PK,Datta S,Banerjee A,Chakraborty S,Rajendran K,Basu SK,Bhattacharya SK,Chakravarty R.Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: exploratory screening reveals high frequency of occult HBV infection[J].World Journal of Gastroenterology,2007,13(27):3730-3733. | |
| Authors: | Bhattacharya Prasun Chandra Partha-Kumar Datta Sibnarayan Banerjee Arup Chakraborty Subhashish Rajendran Krishnan Basu Subir-Kumar Bhattacharya Sujit-Kumar Chakravarty Runu |
| Institution: | 1. Institute of Blood Transfusion Medicine and Immunohematology, Kolkata, India 2. ICMR Virus Unit, Kolkata, India 3. National Institute of Cholera and Enteric Diseases, Kolkata, India |
| Abstract: | AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. |
| Keywords: | Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Blood donation Occult HBV infection |
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