胞磷胆碱钠联合甘露醇和依达拉奉治疗大面积脑梗死疗效观察

目的观察胞磷胆碱钠、甘露醇和依达拉奉联合治疗大面积脑梗死的临床疗效。方法 32例大面积脑梗死患者分为2组,每组16例,2组患者均给予保持呼吸道通畅、吸氧、营养支持等常规治疗,在此基础上,对照组患者给予甘露醇治疗,观察组患者给予胞磷胆碱钠、甘露醇、依达拉奉联合治疗,14 d为1个疗程。治疗1个疗程后,对2组患者的治疗效果及并发症发生率进行比较。结果对照组和观察组患者总有效率分别为68.75%和87.50%,观察组患者治疗总有效率高于对照组(P<0.05)。2组患者治疗第7、14天神经功能缺损评分均显著低于治疗前(P<0.05),治疗前及治疗第7天2组患者神经功能缺损评分比较差异无统计学意义(P>0.05);治疗第14天,观察组患者神经功能缺损评分显著低于对照组(P<0.05)。观察组和对照组患者并发症发生率分别为31.25%、68.75%,观察组患者并发症发生率显著低于对照组(P<0.05)。结论胞磷胆碱钠、甘露醇和依达拉奉联合治疗可明显改善大面积脑梗死患者的临床症状和神经功能。

Effect of citicoline sodium combined with mannitol and edaravone in treatment of patients with massive cerebral infarction

Objective To observe the effect of citicoline sodium combined with mannitol and edaravone in treatment of patients with massive cerebral infarction. Methods Thirty-two patients with massive cerebral infarction were divided into two groups, sixteen patients in each group. The patients in the two groups were treated with maintaining airway patency, oxygen and nutrition support. Based on these, the patients in control group were treated with mannitol, while the patients in observation group were treated with citicoline sodium, mannitol and edaravone. Fourteen days was one course of treatment. The therapeutic efficacy and incidence of complications were compared between the two groups after one course of treatment. Results The total effective rate in control group and observation group was 68.75% and 87.50% ,respectively. The total effective rate in observation group was higher than that in control group （ P 〈 0.05 ）. The ncurologic impairment score on the seventh and fourteenth day after treatment was significantly lower than that before treatment in the two groups（ P 〈 0.05 ）. There was no significant difference in the neurologic impairment score before treatment and the seventh day after treatment in the two groups（P 〉 0. 05 ）. On the fourteenth day after treatment, the neurologic impairment score in observation group was lower than that in control group（ P 〈 0. 05 ）. The incidence of complications in control group and observation group was 31.25% and 68.75% , respectively. The incidence of complications in observation group was significantly lower than that in control group （ P 〈 0.05 ）. Conclusion Citicoline sodium combined with mannitol and edaravone can obviously improve the clinical symptoms and neural function of patients with massive cerebral infarction.