吉西他滨联合顺铂治疗老年晚期恶性肿瘤的临床观察

目的观察吉西他滨联合顺铂治疗老年晚期恶性肿瘤的临床疗效,毒副反应,临床收益反应。方法吉西他滨800mg/m2静脉点滴第1,8,15天;顺铂30mg/m2静脉点滴第2~4天,28天为1周期,完成2周期后评价疗效。至少治疗2个周期。结果64例均可评价,总有效率为46.9%,其中非小细胞肺癌28例,有效率为46.4%,胰腺癌18例,有效率为44.4%,乳腺癌18例,有效率为50%,中位生存期为11个月,疾病进展时间为6.2个月,1年生存率及2年生存率分别为43.8%和23.4%。疾病相关症状显著改善,体力状态改善率62.5%,主要不良反应为骨髓抑制及消化道反应。无治疗相关性死亡。结论吉西他滨联合顺铂化疗治疗老年晚期恶性肿瘤近期有效率较高。毒副反应轻,耐受性好,并可以改善疾病相关症状,值得临床应用。

Gemcitabine plus Cisplatin Combination in Treatment of Elderly Patients with Advanced Cancer

Objective 　To evaluate the efficacy and toxicity of a combination of gemcitabine and cisplatin in elderly patient s with advanced cancer ,the clinical benefitial response. Methods 　Gem 800 mg/ m2 ivdrop d1 ,8 ,15 ;DDP 30 mg/ m2 iv drop d2～4 ,each cycle lasted for 28 days ,at least for 2 cycles. Results 　Sixty $ four patient s were evaluated with 46. 9 % , twenty2eight patient s of NSCLC were evaluated with 46. 4 % ,eighteen patient s of pancreatic cancer were evaluated with 44. 4 % , eighteen patient s of breast cancer were evaluated with 50. 0 %. Median survival time and TTP was 11 months and 6. 2 months ,the curative effect included easement of pain ,obviously improvement of general state ,better quality of exist2 ence and increased KPS score. The main adverse effect s were bone marrow depression ,nausea ,vomitting and so on. There was no t reatment related death. Conclusion 　The elderly patient s with advanced cancer t reated with GP regimen may obtain high remission rate and low toxicity and better tolerated alternative and represent s an option for the t reatment of the elderly patient s with advanced cancer.