| MMP-9和TIMP-1表达与小儿神经母细胞瘤生物学行为相关性研究 |
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| 引用本文： | 秦璐莹,鲍俊涛,李秋芳,张书峰.MMP-9和TIMP-1表达与小儿神经母细胞瘤生物学行为相关性研究[J].中国实用神经疾病杂志,2011,14(22):8-10. |
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| 作者姓名： | 秦璐莹 鲍俊涛 李秋芳 张书峰 |
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| 作者单位： | 1. 郑州大学护理学院 郑州 450052
2. 郑州大学第三附属医院 郑州 450052 |
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| 摘 要： | 目的探讨MMP-9和TIMP-1蛋白与小儿神经母细胞瘤生物学行为之间的关系。方法运用免疫组化S-P法检测56例神经母细胞瘤组织中MMP-9、TIMP-1蛋白的表达。结果 56例神经母细胞瘤组织中41例MMP-9蛋白阳性表达,阳性率为73.2%,MMP-9高表达与神经母细胞瘤临床分期关系密切(P<0.05);29例TIMP-1蛋白阳性表达,阳性率为51.8%,TIMP-1低表达与神经母细胞瘤临床分期关系密切(P<0.05);神经母细胞瘤组织中MMP-9、TIMP-1蛋白表达呈负相关(P<0.05)。结论 MMP-9和TIMP-1蛋白表达与神经母细胞瘤恶性程度、转移和预后关系密切,可作为判断预后和指导治疗的参考指标,并有望成为神经母细胞瘤基因治疗的新靶点。
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| 关 键 词： | 小儿神经母细胞瘤 MMP-9蛋白 TIMP-1蛋白 |
Correlation study between the MMP-9 and TIMP-1 expression with biological behavior in pediatric neuroblastoma |
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| Qin Luying,Bao Juntao,Li Qiufang,et al..Correlation study between the MMP-9 and TIMP-1 expression with biological behavior in pediatric neuroblastoma[J].Chinese Journal of Practical Neruous Diseases,2011,14(22):8-10. |
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| Authors: | Qin Luying Bao Juntao Li Qiufang |
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| Institution: | Qin Luying,Bao Juntao,Li Qiufang,et al.Nursing College of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To detect MMP-9 and TIMP-1 protein in breast cancer and analyze the relationship between these proteins expression and biological behavior.Methods S-P immunohistochemical technique was used to detect the expressions of MMP-9,TIMP-1 proteins among 56 pediatric neuroblastoma.Results The positive rates of MMP-9 and TIMP-1 proteins were 73.2% and 51.8% respectively.The over expression of MMP-9 and the low expression of TIMP-1 protein were significantly related with clinical stage and metastasis.In add... |
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| Keywords: | Pediatric neuroblastoma MMP-9 protein TIMP-1 protein |
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