重型颅脑损伤患者亚低温治疗凝血功能指标的变化与预后

目的观察重型颅脑损伤患者BPC、D-dimer、FIB的变化及与亚低温治疗预后的关系,并探讨重型颅脑损伤患者亚低温治疗的准入指标。方法收集重型颅脑损伤患者68例,随机分为亚低温治疗组及常温治疗组,2组患者除低温相关干预措施不同外,其余治疗方案均相同。治疗时观察分析各患者BPC、D-dimer、FIB变化与预后的相关性。结果 FIB在伤后6 h内,D-dimer在伤后12 h内均出现异常增高,两者在亚低温治疗患者上升程度均较常温组低,随后出现下降趋势。亚低温组无需血小板治疗者的疗效较需输注血小板治疗者好(P=0.000)。结论在颅脑损伤后6 h内开始实施亚低温治疗可以改善预后。曾发BPC<50×109/L患者,预后差,可作为评价预后的指标之一。

Changes of coagulation and outcomes in patients with traumatic brain injury treated by mild hypothermia

Objective To study the changes of BPC,FIB,D-dimer in patients with TBI and their relationship with outcomes when treated with mild hypothermia.Methods Sixty-eight patients suspected with TBI,collected randomly in neurosurgical department of Huizhou First People's Hospital,were divided into mild hypothermia group and normathermia group.Both groups were treated with the same approach except the hypothermal intervention study.And the levels of BPC,D-dimer,FIB were investigated and their correlation with progno...