A study of C-reactive protein in the serum of patients with congestive heart failure |
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| Authors: | ELSTER S K BRAUNWALD E WOOD H F |
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| Affiliation: | 1. Department of Medicine, West Virginia University, Morgantown, West Virginia;2. Division of Cardiovascular Medicine, Heart & Vascular Institute, West Virginia University, Morgantown, West Virginia;3. Division of Cardiovascular Medicine, University of California San Diego, La Jolla, California;1. Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota;2. Baptist Health Louisville, Louisville, Kentucky;1. Department of Emergency Medicine, St Michael''s Hospital, Toronto, Ontario, Canada;2. Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada;3. Department of Emergency Medicine and Cardiovascular Research Institute, Wayne State University, Detroit, Michigan;4. Department of Laboratory Medicine, St Michael''s Hospital, Toronto, Ontario, Canada;5. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada;6. Division of Cardiology, St Michael''s Hospital, Division of Cardiology, Toronto, Ontario, Canada;7. Department of Medicine, University of Toronto, Toronto, Ontario, Canada;8. Applied Health Research Centre, St Michael''s Hospital, Toronto, Ontario, Canada;9. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada;10. Departments of Anaesthesia and Critical Care, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael''s Hospital, Toronto, Ontario, Canada;11. Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada |
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| Abstract: | Forty patients manifesting congestive heart failure have been studied with serial serum determinations for C-reactive protein. This abnormal protein was found in thirty instances. No demonstrable difference in age, sex, or race were noted between the two groups. In those patients in whom C-reactive protein was present, the congestive heart failure appeared to be more severe. Fever, elevated erythrocyte sedimentation rate, and pulmonary abnormalities were more common in the group in which C-reactive protein occurred.In approximately one-half of the group in which C-reactive protein was found, the protein was initially present but disappeared after one to two weeks of treatment. In six patients, the C-reactive protein persisted in the blood throughout the hospital course.Single determinations of C-reactive protein were made in the blood of ten patients in whom congestive heart failure was stationary. In no instance was C-reactive protein present.The presence of C-reactive protein in the blood of patients with congestive heart failure limits the application of C-reactive protein determinations as a measure of rheumatic activity in acute rheumatic fever and in chronic rheumatic heart disease and as a measure of necrosis in acute myocardial infarction. |
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