Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents |
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| Authors: | Rahul P. Modh Amit C. Patel Dharmesh H. Mahajan Christophe Pannecouque Erik De Clercq Kishor H. Chikhalia |
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| Affiliation: | 1. Department of Chemistry, Gujarat University, Ahmedabad, Gujarat, India;2. Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, India;3. Department of Chemistry, Uka Tarsadia University, Tarsadi, Gujarat, India;4. Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium |
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| Abstract: | In an attempt to afford possible antibacterial and anti‐human immunodeficiency virus (HIV) agents, a series of 22 novel styryl quinazoline‐based heterocyclic entities were designed and synthesized. Various substituted aryl urea and thiourea cores were incorporated at position 4 of quinazoline, followed by styrylation of position 2, aiming at an augmented biological potential. The synthesized compounds were well characterized through IR, 1H NMR, 13C NMR and elemental analyses. All compounds were screened for their in vitro anti‐HIV activity against the HIV‐1 (IIIB) and HIV‐2 (ROD) strains. The antibacterial activity was also evaluated against various pathogenic Gram‐positive and Gram‐negative bacterial strains. |
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| Keywords: | Antibacterial Anti‐HIV Aryl thiourea Aryl urea Quinazoline Styryl |
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