Mitochondrial Division in Rat Cardiomyocytes: An Electron Microscope Study |
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| Authors: | Hisashi Fujioka Bernard Tandler Charles L. Hoppel |
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| Affiliation: | 1. Electron Microscopy Facility and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;2. Department of Biological Sciences, School of Dental Medicine, and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;3. Center for Mitochondrial Disease, and Departments of Pharmacology and of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA |
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| Abstract: | In cardiomyocytes of rats, two distinct mitochondrial division processes are in operation. The predominant process involves extension of a single crista until it spans the full width of a mitochondrion. Ingrowth of the outer membrane ultimately results in scission. The second division process involves “pinching,” in which narrowing of the organelle at specific surface locations leads to its attenuation. When limiting membranes from opposite sides meet, mitochondrial fission ensues. When pinching is the operative mode, elements of sarcoplasmic reticulum always are associated with the membrane constrictions. The nuclear control mechanisms that determine which modality of mitochondrial division will prevail are unknown. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | mitochondrial division mitochondrial pinching cardiac heart |
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