| 柴胡桂枝汤对肝纤维化大鼠FN、a-SMA表达的影响 |
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| 引用本文： | 李林蔚,周景华,刘华生.柴胡桂枝汤对肝纤维化大鼠FN、a-SMA表达的影响[J].黑龙江医药,2014,0(2):265-267. |
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| 作者姓名： | 李林蔚 周景华 刘华生 |
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| 作者单位： | 李林蔚(黑龙江中医药大学中医基础诊断教研室 黑龙江哈尔滨 150040)；周景华(黑龙江中医药大学附属第一医院 黑龙江哈尔滨 150040)；刘华生(黑龙江中医药大学中医基础诊断教研室 黑龙江哈尔滨 150040)； |
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| 基金项目： | 黑龙江省研究生创新科研资助项目(项目编号：D2005-37) |
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| 摘 要： | 目的：观察柴胡桂枝汤对肝纤维化大鼠纤维连接蛋白（FN）和a．平滑肌动蛋白（a-SMA）表达的影响。方法：采用CCI．复合法制备肝纤维化大鼠模型；用免疫组化方法观察实验动物模型肝脏中FN、a-SMA表达的情况。结果：柴胡桂枝汤可抑制肝纤维化大鼠肝脏中FN、a-SMA的表达，中药中等浓度组FN和a-SMA的表达水平明显低于模型组、中药高剂量组、中药低剂量组和西药对照组，具有极显著性差异（P〈O．01）。结论：柴胡桂枝汤能够有效的控制纤维化肝脏中FN、a-SMA的高表达。抑制HSC活化，具有抗肝纤维化的作用。
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| 关 键 词： | 肝纤维化 柴胡桂枝汤 FN a-SMA |
Effect of Chaihu Guizhi Decoction on Expression of FN and a-SMA of Rats with Liver Fibrosis |
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| Institution: | LI Linwei, et al (Heilongfiang University of Chinese Medicine, (Harbin 150040, China )) |
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| Abstract: | Objective： To investigate the effect of Chaihu Guizhi decoction on the expression of fibronectin（FN） and alpha smooth musele actin（a-SMA） in rats with liver fibrosis. Methods： Rat models of liver fibrosis were made by CC14 compound method.The effect of Chaihu Gnizhi decoction on the expression of FN and a-SMA of rats with liver fibrosis were observod by immunohistochemical method. Results： Chaihu Guizhi decoction could control the expression of FN and a-SMA in rats with liver fibrosis. Compared with the model group and high concentration of Chinese medicine group and low concentration of Chinese medicine group and Western Medi- cine group, the expression level of Fn and a-SMA in middle concentration of Chinese medicine group possessed a significant difference （ P 〈 0.01）. Conclusion： Chaihu Guizhi decoction can control the high expression levels of FN and a-SMA in rats with liver fibrosis, Inhibition of HSC was activated,and can plays an important role in the recovery of liver fibrosis. |
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| Keywords: | Liver fibrosis Chaihu Guizhi decoction FN a-SMA |
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