Focal nodular hyperplasia of the liver on ferumoxides-enhanced MR imaging: features on conventional spin-echo, fast spin-echo and gradient-echo pulse sequences |
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Authors: | S Precetti-Morel M F Bellin L Ghebontni S Zaïm P Opolon T Poynard P Mathurin P Cluzel |
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Institution: | Department of Radiology, Pitié-Salpétrière Hospital and University Paris VI, 83 Boulevard de l'H?pital, F-75651 Paris Cedex 13, France, FR Department of Hepatology, Pitié-Salpétrière Hospital and University Paris VI, 83 Boulevard de l'H?pital, F-75651 Paris Cedex 13, France, FR
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Abstract: | The aim of this study was to assess the efficacy of a superparamagnetic iron oxide, ferumoxides, in the detection and characterization
of focal nodular hyperplasia (FNH) on MR conventional spin-echo (SE), fast spin-echo (FSE) and gradient-echo (GRE) images.
Fourteen adults with 27 FNHs were evaluated at 1.5 T before and after injection of ferumoxides. T1-weighted and T2-weighted
SE, T2-weighted FSE and T2*-weighted GRE sequences were used and analysed qualitatively and quantitatively. One hundred percent of FNHs showed a significant
postcontrast decrease in signal intensity on T2- and T2*-weighted images. Heavily T2-weighted SE images showed the maximum
decrease in FNH signal-to-noise ratio (S/N). Postcontrast GRE T2*-weighted images improved the detection of the central scar and the delineation of FNHs and demonstrated the best lesion-to-liver
contrast-to-noise ratio (C/N). Postcontrast T1-weighted SE images showed the least lesion-to-liver C/N. Ferumoxides-enhanced
MR imaging can help detect and characterize FNH. Conventional pre- and postcontrast T2-weighted SE images and postcontrast
GRE T2*-weighted images should be used preferentially.
Received: 30 November 1998; Revised: 5 April 1999; Accepted: 6 April 1999 |
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Keywords: | : MR imaging Contrast enhancement Liver Neoplasm Focal nodular hyperplasia |
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