五种肿瘤标志物联合检测在胃和结直肠癌诊断及随访中的临床意义

目的评价CA199、CEA、CA242、CA125、CA153五种血清肿瘤标志物联合检测对胃、结直肠癌诊断和随访的价值。方法分别采用电化学发光分析法测定检测165例胃、结直肠癌患者和82例胃、结直肠良性疾病患者及160例健康人血清中5种肿瘤标志物的水平。结果肿瘤组的肿瘤标志物水平显著高于良性疾病组及健康组(P<0.01)。肿瘤根治术后,肿瘤标志物水平显著下降;术后未降至正常者,复发或转移率为71.05%,而术后再升高者复发或转移率为76%。结论上述多种肿瘤标志物对胃和结直肠癌的诊断和随访监测肿瘤复发、转移有一定的价值。采用平行检测法,可以提高检测的敏感度和阴性预测值;采用系列检测,可提高检测的特异度和阳性预测值。

Clinical Significance of Combined Assay of Five Serum Tumor Markers in Diagnosis and Follow-up of Gastric Cancer and Colorectal Carcinoma

Objective To evaluate the measurement of the serum levels of CA199,CEA,CA242,CA125 and CA153 in gastric cancer and colorectal carcinoma diagnosis and follow-up.Methods The serum levels of the 5 kinds of serum tumor markers,were measured using electroche miluminescene analyzer in 165 patients with gastric cancer and colorectal carcinoma,82 patients with benign digestive disease and 160 healthy examinations.Results The levels of the 5 kinds of serum tumor markers were significantly higher in gastric cancer and colorectal Carcinoma than that of two other controls(P<0.01).The levels of serum tumor markers declined significantly after radical operation.The rate of recurrence or metastasis was 71.05% in that the levels of serum tumor markers were not decreased to normal after radical operation.The rate of recurrence or metastasis was 76% in patients that the levels of serum tumor markers were reelevated after radical operation.Conclusion The various serum tumor markers mentioned above have certain value in the diagnosis and the following up for the gastric cancer and colorectal carcinoma and can be used to monitor tumor recurrence and metastasis.The simultaneously combined assay raised sensitivity and negative predictive rate;the serial combined assay can raise specificity and positive predictive rate.