| 高效液相色谱-质谱联用测定人血浆中辛伐他汀浓度 |
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| 引用本文： | 王菁,刘史佳,居文政. 高效液相色谱-质谱联用测定人血浆中辛伐他汀浓度[J]. 中国药房, 2007, 18(5): 347-349 |
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| 作者姓名： | 王菁 刘史佳 居文政 |
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| 作者单位： | 1. 江苏先声药物研究有限公司,南京市,210042
2. 江苏省中医院临床药理实验室,南京市,210029 |
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| 摘 要： | 目的建立测定人血浆中辛伐他汀浓度的方法。方法血浆样品中加入内标,用乙醚提取,浓缩后采用高效液相色谱-质谱联用进行测定。结果血浆样品中辛伐他汀线性范围为0.1～20ng·mL-1(r=0.9999);萃取回收率为94.3%。结论本方法灵敏度高、专属性强、重现性好、准确,可用于辛伐他汀片人体药动学及生物等效性研究。
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| 关 键 词： | 辛伐他汀 高效液相色谱-质谱联用法 浓度 |
| 文章编号： | 1001-0408（2007）05-0347-03 |
| 收稿时间： | 2006-06-23 |
| 修稿时间： | 2006-07-26 |
Determination of Simvastatin in Human Plasma by LC/MS/MS |
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| WANG Jing,LIU Shijia,JU Wenzheng. Determination of Simvastatin in Human Plasma by LC/MS/MS[J]. China Pharmacy, 2007, 18(5): 347-349 |
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| Authors: | WANG Jing LIU Shijia JU Wenzheng |
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| Abstract: | OBJECTIVE:To establish a method for the determination of simvastatin level in human plasma.METHODS:The plasma samples, into which the internal standard was added,were extracted with Ethyl Ether,then concentrated and determined by LC/MS/MS.RESULTS:The linear range of simvastatin was 0.1～20ng·mL-1(r=0.999 9),with extraction recovery rate at 94.3%.CONCLUSION:The method is sensitive,specific,reproducible and accurate,and suitable for the study of pharmacokinetics and bioequivalence of simvastatin in human body. |
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| Keywords: | Simvastatin LC/MS/MS Concentration |
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