| 氯仿、氯苯和多氯联苯对染毒家兔红细胞脂质过氧化和膜流动性的影响 |
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| 引用本文： | 薛建华,王近中,辛佩珠,殷明.氯仿、氯苯和多氯联苯对染毒家兔红细胞脂质过氧化和膜流动性的影响[J].中华预防医学杂志,1994(5). |
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| 作者姓名： | 薛建华 王近中 辛佩珠 殷明 |
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| 作者单位： | 海军医学研究所 |
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| 摘 要： | 比较了氯仿、氯苯和多氯联苯三种氯代化合物对染毒家兔红细胞脂质过氧化和膜流动性的影响。结果发现，每天给家兔腹腔注射含有上述毒物的花生油溶液，对红细胞脂质过氧化具有程度不等的４酶促进作用，但对膜脂流动性的影响并不一致，氯仿有促流效应，多氯联苯的作用相反，说明毒物分子的结构特性也对膜流动性具有影响。此外发现，膜流动性可能与细胞形态的维持有关。
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| 关 键 词： | 氯仿，氯苯类，多氯联苯化合物，脂质过氧化物，红细胞膜 |
Effects of Chloroform,Chlorobenzene and Polychlorinated Bipkenyls on Erythrocyte Lipld Peroxidation and Membrane Fluidity in Poisoned Rabbits |
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| Xue Jian-hua,Wang Jin-zhong,Xin Pei-zhu,et al..Effects of Chloroform,Chlorobenzene and Polychlorinated Bipkenyls on Erythrocyte Lipld Peroxidation and Membrane Fluidity in Poisoned Rabbits[J].Chinese Journal of Preventive Medicine,1994(5). |
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| Authors: | Xue Jian-hua Wang Jin-zhong Xin Pei-zhu |
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| Institution: | Xue Jian-hua,Wang Jin-zhong,Xin Pei-zhu,et al.,Naval Medical Research Institute PLA of China,Shanghai,200433 |
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| Abstract: | ffects of three chlorinated compounds,i.e chloroform,chlorobenzene and Aroclor 11l254 (PCB8),on lipid peroxidation and membrane fluidity of erythrocytes in poisoned rabbits were studied. Results revealed daily intraperitoneal injection of peanut oil containing chlorinated compounds into rabbits showed nonenzymic promotion effects on its erythrocyte lipid peroxidation in varying degrees,but dif-ferent effects on erythrocyte membrane fluidity,promoting by chloroform and inhibiting by Aroclor l254.It suggested the constitutional characteristics of toxicant molecules also had effects on membrane fluidity.In addition, it was found there existed potential relationship between maintenance of cell momhology and membrane fluidity. |
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| Keywords: | Chloroform Chlorobenzenes Polychlorobiphenyl compounds Lipid pero-xides Erythrocyte membrane |
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