Maternal serum AMP-activated protein kinase levels in mild and severe preeclampsia |
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| Authors: | Nadiye Koroglu Esra Tola Ilkbal Temel Yuksel Berna Aslan Cetin Ugur Turhan Goknur Topcu |
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| Affiliation: | 1. Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey;2. Obstetrics and Gynecology Department, Suleyman Demirel University, Faculty of Medicine, Istanbul, Turkey;3. Department of Obstetrics and Gynecology, Maternal-Fetal Medicine Unit, Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital, School of Medicine, University of Saglik Bilimleri, Istanbul, Turkey |
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| Abstract: | Objective: To investigate Phosphorylated adenosine monophosphate activated protein kinase (AMPK) levels in healthy pregnant women and pregnant women with preeclampsia (PE).Methods: Twenty-eight women with mild-PE, 22 with severe-PE, and 30 normotensive controls were included in this cross-sectional study. The serum AMPK levels of these patients were analyzed. The patients were followed up to delivery.Results: No statistically significant difference was found between the groups for age, gravida, parity, and gestational age at the time the blood samples were obtained (p?>?.05). No significant difference between the group with mild-PE and the control group was found, while in the severe-PE group, serum AMPK levels were significantly higher relative to both the mild-PE and control groups (p?p?Conclusions: Serum AMPK was higher in patients with severe-PE compared with healthy pregnant women and patients with PE without severe features so it might be a new biomarker for the prediction of disease and its severity. |
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| Keywords: | AMP-activated protein kinase preeclampsia pregnancy |
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