A diagnostic test accuracy meta-analysis of maternal serum ischemia-modified albumin for detection of preeclampsia |
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Authors: | Varikasuvu Seshadri Reddy Manne Munikumar Pragathi Duggina Neelakant Varma |
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Affiliation: | 1. Department of Biochemistry, Maheshwara Medical College &2. Hospital, Patancheru, India;3. Biomedical Informatics Center (BMIC), National Institute of Nutrition – Indian Council of Medical Research, Hyderabad, India;4. Technology Business Incubator, Sri Padmavati Mahila Visvavidyalayam, Tirupati, India;5. Laboratory of Forensic Biology and Biotechnology, Institute of Forensic Science, Gujarat Forensic Sciences University, Gandhinagar, India |
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Abstract: | Background/aims: Ischemia-modified albumin (IMA) has been widely accepted as a serological biomarker. IMA has been proposed as a simple and novel marker of oxidative stress in preeclampsia (PE). This systematic review and diagnostic test accuracy meta-analysis aims to evaluate the diagnostic accuracy of this novel serological biomarker, IMA to detect PE.Methods: A systematic search of major databases was performed to identify all published diagnostic accuracy studies on IMA. Risk of bias and applicability concerns were assessed for included studies. Summary estimates; the pooled sensitivity, specificity, and the diagnostic odds ratio (DOR) of IMA for the diagnosis of PE were computed using random-effects models. The overall test performance was summarized using summary receiver operating characteristic (SROC) curve analysis.Results: Six articles were included in this meta-analysis. The overall estimates of IMA in detecting PE were pooled sensitivity; 0.80 (95%CI 0.73–0.86), pooled specificity; 0.76 (95%CI 0.70–0.81), DOR; 14.32 (95%CI 5.06–40.57), and area under curve (AUC); 0.860. There was no between-study heterogeneity due to threshold effect.Conclusions: This meta-analysis showed IMA could be useful as a biomarker for PE with good accuracy (AUC?=?0.860). However, further research is needed for re-evaluation and clinical validation of fairly promising results of this meta-analysis. |
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Keywords: | Ischemia-modified albumin preeclampsia diagnostic accuracy meta-analysis |
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