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An update on calcium carbonate nanoparticles as cancer drug/gene delivery system |
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| Authors: | Solmaz Maleki Dizaj Simin Sharifi Elham Ahmadian Aziz Eftekhari Khosro Adibkia |
| Institution: | 1. Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Pharmacology and Toxicology, Maragheh University of Medical Sciences, Maragheh, Iran;3. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran |
| Abstract: | Introduction: In recent years, the applications of calcium carbonate (CaCO3) nanoparticles (NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous tissues and cells due to their accessibility, low cost, safety, biocompatibility, pH-sensitivity, and slow biodegradability. Areas covered: Drug-loaded CaCO3 NPs (CCNPs) have been reviewed. An updated search on the current state of CCNPs as cancer drug/gene delivery systems with a focus on their special properties including pH-sensitivity, biodegradability, and sustained release performance has been also assessed. Expert opinion: Based on the reviewed literature, CCNPs, because of their superior features, will have a great aiding role in safe and efficient cancer treatment in the near future. |
| Keywords: | CaCO3 nanoparticles cancer drug delivery gene delivery |