Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy |
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| Authors: | Ahter Tanay Tayyar Sukran Kozalı Gonca Yetkin Yildirim Resul Karakus Ilkbal Temel Yuksel Ozcan Erel |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Health Sciences University, Zeynep Kamil Maternity and Children’s Training and Research Hospital, ?stanbul, Turkey;2. drahtertayyar@yahoo.com;4. Department of Obstetrics and Gynecology, Health Sciences University, Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey;5. Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey |
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| Abstract: | Objective: The objective of this study is to investigate the ischemia-modified albumin (IMA) level, and the IMA/albumin ratio (IMAR) in healthy pregnant women, and pregnant women with intrahepatic cholestasis of pregnancy (ICP).Material and method: This cross-sectional study included 53 women with ICP and 52 healthy pregnant women. Their serum IMA and albumin levels were analyzed, and the women were followed up to delivery.Results: No significant intergroup differences were identified in maternal age, body mass index, and gestational age at the time that the blood samples were taken. The gestational age at delivery and the serum albumin level was significantly lower (p?=?.002 and p?p?=?.004).Conclusion: Serum IMA levels did not differ between pregnant women with ICP and healthy pregnant women, while the IMAR was significantly higher in the ICP group versus the healthy pregnant women. |
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| Keywords: | Bile acids cholestasis ischemia-modified albumin oxidative stress pregnancy |
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