|
|||||
|
|
Omics of antimicrobials and antimicrobial resistance |
|
| Authors: | Vladislav M Chernov Olga A Chernova Alexey A Mouzykantov Leonid L Lopukhov |
| Institution: | 1. Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Kazan, Russian Federation;2. Institute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Russian Federation;3. Institute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Russian Federation |
| Abstract: | Introduction: The development of new antimicrobials has become an urgent priority because of a global challenge emerging from the rise of antimicrobial resistant pathogens. Areas covered: In this review, the authors discuss the opportunities offered by modern omics approaches to address the challenge and the use of this approach in antimicrobial development. Specifically, the authors focus on the role of omics technologies and bioinformatics for the revelation of the effects of antimicrobials in a variety of microbial cellular processes, as well as the identification of potential cellular targets, the mechanisms of antimicrobial resistance, and the development of new antimicrobials. Expert opinion: Prevention of antimicrobial resistance does not only depend on rational drug design such as narrow-spectrum antimicrobials but on several factors. It is the opinion of the authors that the use of a multi-omics bioinformatics approach should become an integral part of antimicrobial drug discovery as well as in the prevention of antimicrobial resistance. |
| Keywords: | |