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Successful treatment of a BRAF V600E-mutant extracranial metastatic anaplastic oligoastrocytoma with vemurafenib and everolimus |
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| Authors: | Liangliang Shi Zhenwei Zou Qian Ding Qing Liu Hongxia Zhou Xiaohua Hong |
| Affiliation: | 1. Cancer center, Union hospital, Tongji medical college, Huazhong university of science and technology, Wuhan, China;2. Department of oncology, Union hospital, Fujian medical university, Fuzhou, China |
| Abstract: | Background: Extracranial metastasis is a rare phenomenon of anaplastic oligoastrocytoma. When patients progress after comprehensive treatment, there is often no effective treatment. Rapid development of gene detection technology makes precision treatment of glioma possible. Patient and methods: A 22-year-old girl was firstly diagnosed with anaplastic oligoastrocytoma WHO grade III-IV in 2014, and progressed rapidly after chemoradiotherapy in multiple extraneural lesions in 2016. She was expected to have a short life and Next-Generation Sequencing (NGS) was applied. Results: Mutation of BRAF (V600E) was reported by 1st NGS and oral vemurafenib stabilized her disease for 6 months. PIK3CA was reported by 2nd NGS after her progression of vemurafenib. The oral administration of everolimus together with vemurafenib stabilized her disease for another 6 months. However, the patient died due to the rapid progression of the disease on 24 February 2018. Conclusion: We successfully treated a BRAF V600E-mutated anaplastic oligoastrocytoma with multiple extraneural metastases with vemurafenib and everolimus. For late-staged patients who have no clear and effective treatment plan, NGS may serve as an effective option. |
| Keywords: | Oligoastrocytoma Vemurafenib everolimus BRAF mTOR PIK3CA next-generation sequencing cancer genomics gene therapy tumor metastases |