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The association between nonalcoholic fatty liver disease and risk of colorectal adenoma and cancer incident and recurrence: a meta-analysis of observational studies |
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| Authors: | Jin Chen Dongxue Bian Shufei Zang Zongxing Yang Guoyan Tian Yan Luo |
| Institution: | 1. Department of Postgraduates, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China;2. Department of Digestive Disease, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu, China;3. Department of Endocrinology, The Fifth Affiliated Hospital of Fudan University, Shanghai, China;4. Department of Infectious Disease, Hangzhou Xixi hospital, Hangzhou, Zhejiang, China;5. Department of Transformation Medical platform, Hangzhou Normal University Affiliated Hospital, Hangzhou, Zhejiang, China |
| Abstract: | Background & aim: Lifestyle modification plays a key role in nonalcoholic fatty liver disease (NAFLD) and colorectal adenoma and/or cancer (CRA/CRC) development. However, the association between NAFLD and the risk of CRA/CRC has not been carefully evaluated. Methods: In this meta-analysis, we assessed 21 eligible studies including 124,206 participants to determine the association between NAFLD and the risk of incident and recurrent CRA/CRC. Results: NAFLD presence was associated with an increased risk of any incident CRA (aOR: 1.30, 95% CI: 1.19–1.43) and advanced incident CRA/CRC (aOR: 1.57, 95% CI: 1.21–2.04). The severity of NAFLD affected this correlation: compared to mild and/or moderate NAFLD, severe NAFLD was associated with an increased risk of incident CRA/CRC (aOR: 2.19, 95% CI: 1.33–3.60). Although pooled cOR revealed that NAFLD was associated with an increased risk of recurrent CRA/CRC (cOR = 1.73; 95% CI: 1.12–2.68), after adjustment for confounding factors, NAFLD had less correlation with the risk of recurrent CRA/CRC (aOR: 1.81, 95% CI: 0.70–4.65). Conclusions: The presence and severity of NAFLD are associated with an increased risk of incident CRA/CRC. However, there is insufficient evidence to indicate that NAFLD is associated with an increased risk of recurrent CRA/CRC. |
| Keywords: | Colorectal adenoma colorectal cancer meta-analysis nonalcoholic fatty liver disease observational study |