| 初诊2型糖尿病患者采用胰岛素强化治疗对胰岛β细胞分泌功能的影响 |
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| 引用本文： | 张彦红.初诊2型糖尿病患者采用胰岛素强化治疗对胰岛β细胞分泌功能的影响[J].吉林医学,2005,26(6):574-575. |
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| 作者姓名： | 张彦红 |
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| 作者单位： | 天津华兴医院内科 天津300270 |
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| 摘 要： | 目的:探讨初诊2型糖尿病患者采用胰岛素强化治疗对胰岛β细胞功能的影响。方法:对初诊2型糖尿病患者在胰岛素强化治疗3个月前后行葡萄糖耐量试验及同步胰岛素激发试验,比较BG、INS及I30/G30的变化。结果:BG明显下降,INS及I30/G30升高(P<0.05)。结论:对初诊2型糖尿病患者采用胰岛素强化治疗,通过降低糖毒性、脂毒性,可保护和显著恢复胰岛β细胞分泌功能。
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| 关 键 词： | 葡萄糖毒性 脂毒性 β细胞功能 |
| 文章编号： | 1004-0412(2005)06-0574-02 |
| 修稿时间： | 2005年11月24 |
The effects of intensive insulin treatment on beta-cell excretive function in newly diagnosed type 2 diabetic patients |
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| ZHANG Yan-hong.The effects of intensive insulin treatment on beta-cell excretive function in newly diagnosed type 2 diabetic patients[J].Jilin Medical Journal,2005,26(6):574-575. |
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| Authors: | ZHANG Yan-hong |
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| Abstract: | Objective To study the impact of short-term intensive insulin treatment on β-cell function in newly diagnosed type 2 diabetic patients. Method Newly diagnosed type 2 diabetic patients were treated with glucose tolerance test and isochronous insulin excitated test for three months before and after the intensive insulin treatment. The BG,INS and I30/G30 were compared. Results BG was significantly decreased, INS and I30/G30 were increased (P<0.05). Conclusion The pancreatic β-cell function can be protect and significantly resumed by decreasing the glucose toxicity and lipotoxicity in newly diagnosed type 2 diabetic patients. |
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| Keywords: | Glucose toxicity Lipotoxicity β-cell function |
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