磷酸化mTOR在恶性黑素瘤中的表达及与CyclinD1的关系

目的探讨磷酸化哺乳动物雷帕霉素靶蛋白（p-mTOR）在恶性黑素瘤中的表达，及其与恶性黑素留临床病理特征和细胞周期蛋白D1（CyclinD1）表达的关系。方法采用免疫组化法检测43例恶性黑素瘤、20例色素痣中p-mTOR和CyclinD1的表达。结果①p-roTOR和CyclinD1在恶性黑素瘤的阳性表达率明显高于色素痣；②p-mTOR在恶性黑素瘤的表达与浸润深度、淋巴结转移有关，与性别、年龄无关；③恶性黑素瘤中p-mTOR与CyclinD1的表达呈显著正相关。结论恶性黑素瘤的发生发展可能与mTOR信号通路诱导CyclinD1过度表达有关。

Expression of phosphorylated-mTOR and its relationship with CyclinD1 in malignant melanoma

Objective To investigate the expression of phosphorylated-mammalian target of rapamycin（p-mTOR） and its relationship with the clinicopathological characters and the expression of CyclinD1 in malignant melanoma. Methods Immunohistochemistry method was used to measure the expression of p-mTOR and CyclinDl in specimens from 43 cases of malignant melanoma and 20 cases of pigmented nevus. Results （1）Positive rate of p-mTOR and CyclinD1 expression in malignant melanoma was significantly higher than that in pigmented nevus. （2）The expression of p-mTOR in malignant melanoma was correlated with the depth of infiltration and lymph node metastasis, but not with age or gender. （3）There existed positive correlation between the expression of p-mTOR and CyclinD1 in malignant melanoma. Conclusion The activation of roTOR vathwav may induce overexpression of CyclinD1 ,which may be related to the occurrence and development of malignant melanoma.