参附注射液对心脏瓣膜置换术患者心功能的保护作用研究

目的：探讨参附注射液(SF)对体外循环下心脏瓣膜置换术患者的心脏保护作用。方法：选择体外循环下行瓣膜置换术患者120例，随机分为参附组(SF组，60例)和对照组(C组60例)，SF组麻醉前30min静脉输入参附注射液1mg·kg^-1，C组输入等量生理盐水。观察：(1)术中血流动力学变化；(2)术中及术后血管活性药物的使用；(3)术后康复时间。结果：SF组术中平均动脉压(MAP)、心率(HR)高于C组，中心静脉压(CVP)低于C组(P<0．05)；SF组术中及术后多巴胺、多巴酚丁胺、硝普钠、利多卡因使用剂量低于C组(P<0．05)；SF组术后拔管时间、重症监护室留置时间短于C组(P<0．05)。结论：参附注射液(SF)对体外循环下心脏瓣膜置换术患者的心功能有一定保护作用。

Study on Protective Effect of Shenfu Injection on Cardiac Function of Patients Undergoing Valve Replacement

Objective:To investigate the protective effect of Shenfu injection (SFI) on cardiac function of patients undergoing valve replacement operation under cardio-pulmonary bypass. Methods:One hundred and twenty patients undergoing valve replacement operation under cardio-pulmonary bypass were randomly divided into the SFI group and the control group, 60 in each group. Intravenous infusion of 1 ml/kg SFI was given to the SFI group, 30 min before anesthesia, and to the control group, equal volume of normal saline was given instead. The following indices were observed: (1) the hemodynamic changes occurred in the operational period; (2) the dosage of vaso-active drugs used during and after operation; (3) the post-operational recovery time of patients. Results:The mean arterial pressure and heart rate in the SFI group during operation were higher, while the central venous pressure was lower than those in the control group (P<0.05). The dosage of vaso-active drugs, such as dopamine, dobutamine, sodium nitroprusside and lidocaine, used during and after operation was lower, and the extubation time and the intensive care unit (ICU) staying time were shorter in the SFI group when compared with those in the control group (P<0.05). Conclusion:SFI has certain protective effects on the cardiac function of patients undergoing valve replacement operation under cardio-pulmonary bypass.