Microcirculatory effects of pulsed electromagnetic fields |
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| Authors: | Thomas L. Smith Donna Wong‐Gibbons Jane Maultsby |
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| Affiliation: | 1. School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100, USA;2. ExxonMobil Research and Engineering, 1545 Route 22 East, Annandale, NJ 08801, USA;1. Research Clinical Center of JSC “Russian Railways”, Moscow, Russia;2. Russian National Research Medical University, Moscow, Russia;3. Space Research Institute, RAS, Moscow, Russia;4. Prokhorov General Physics Institute, RAS, Moscow, Russia;1. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, NCSU CVM VHC #2563, 1052 William Moore Drive, Raleigh, NC 27607-4065, USA;2. Gulf Coast Veterinary Specialists, 1111 West Loop South, Houston, TX 77027, USA;3. Private Practice, 2285 Bristol Circle, Oakville, Ontario L6H 6P8, Canada;1. Department of Neuroscience, Section of Physiotherapy, Uppsala University, Uppsala, Sweden;2. Evidensia Djurkliniken Gefle, Gävle, Sweden;3. Unit of Research, Education and Development, Region Jämtland Härjedalen, Östersund, Sweden;4. Department of Health Sciences, Mid Sweden University, Östersund, Sweden;5. Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden;6. Canine Fitness Centre, Calgary, Alberta, Canada;1. Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, City Hospital, Dudley Road, Birmingham, B18 7QH, UK;2. Doncaster Royal Infirmary, Doncaster, UK;3. School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK |
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| Abstract: | Purpose: Pulsed electromagnetic fields (PEMF) are used clinically to expedite healing of fracture non‐unions, however, the mechanism of action by which PEMF stimulation is effective is unknown. The current study examined the acute effects of PEMF stimulation on arteriolar microvessel diameters in the rat cremaster muscle. The study hypothesis was that PEMF would increase arteriolar diameters, a potential mechanism involved in the healing process. Methods: Local PEMF stimulation/sham stimulation of 2 or 60 min duration was delivered to the cremaster muscle of anesthetized rats. Arteriolar diameters were measured before and after stimulation/sham stimulation using intravital microscopy. Systemic hemodynamics also were monitored during PEMF stimulation. Results: Local PEMF stimulation produced significant (p < 0.001) vasodilation, compared to pre‐stimulation values, in cremasteric arterioles in anesthetized rats (n = 24). This dilation occurred after 2 min of stimulation (9% diameter increase) and after 1 h of stimulation (8.7% diameter increase). Rats receiving “sham” stimulation (n = 15) demonstrated no statistically significant change in arteriolar diameter following either “sham” stimulation period. PEMF stimulation of the cremaster (n = 4 rats) did not affect systemic arterial pressure or heart rate, nor was it associated with a change in tissue environmental temperature. Conclusions: These results support the hypothesis that local application of a specific PEMF waveform can elicit significant arteriolar vasodilation. Systemic hemodynamics and environmental temperature could not account for the observed microvascular responses. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved. |
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| Keywords: | PEMF Microcirculation Rats Vascular mechanisms |
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